重组人生长激素治疗烧伤患者68例临床分析

Wound healing effects of recombinant human growth hormone therapy:clinical analysis of 68 burn patients

目的:观察重组人生长激素(rhGH)对烧伤患者的疗效。方法:选择68例烧伤患者为对象,随机分为rhGH组和对照组,每组34例。rhGH组从伤后第3 d开始每日给予rhGH皮下注射,持续14 d。对照组同法注射等量等渗盐水。动态监测创面的愈合时间、住院天数等基础指标;治疗期间定期检测患者的蛋白质代谢、糖代谢、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)的变化。结果:rhGH组创面愈合时间与住院天数较对照组明显缩短(P<0.05)。与对照组相比,用药7 d后rhGH组血红蛋白、血浆蛋白及血糖水平明显升高(P<0.05),但未出现难以控制的高血糖;TNF-αI、L-6水平显著降低(P<0.05)。结论:使用rhGH有助于改善全身状况,促进创面愈合,缩短住院时间,还可调节烧伤患者的高代谢反应,促进蛋白质合成,改善营养状况,增强免疫功能,是临床上安全、可靠的治疗方法。

Objective： To observe the wound healing effects of recombinant human growth hormone（rhGH） on patients with burning wounds.Methods： A total of 68 patients with burning wounds were randomly divided into rhGH group and control group with 34 cases in each group.The rhGH group was given subcutaneous rhGH daily for 14 days,while the control group was given isotonic saline solution at the same dosage.During the treatment course,wound healing length,hospital stay were checked,and changes in protein metabolism, glucose metabolism, tumor necrosis factor （TNF-α）, interleukin 6 （II-6） were monitored. Results： Comparing with the control group, the rhGH group showed significant shorter wound healing time and hospital stay （P〈0.05）; seven days after treatment, the hemoglobin, plasma protein levels and blood glucose levels increased significantly in the rhGH group （P〈0.0 5）, no ease of uncontrolled blood glucose levels were presented; meanwhile TNF-α, II-6 levels were significantly decreased （P〈0.05）. Conclusions. For patients with burning wounds, rhGH can help to improve their general conditions, promote wound healing process, adjust the high metabolic responses, promote protein synthesis, as well as enhance patients＇ immune function. It＇s also safe and effective.