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EphA2及其与肿瘤关系的研究进展

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摘要 酪氨酸蛋白激酶受体（RTKs）是将细胞外信息传递至细胞核发挥细胞效应,在细胞信号传导通路起重要作用,参与细胞的增生、分化、胚胎发育和细胞内信号转导以及肿瘤的形成过程中,具有重要的生理功能。
作者 李才政 李庆文
机构地区 蚌埠医学院第一附属医院泌尿外科
出处 《蚌埠医学院学报》 CAS 2011年第1期107-108,F0003,共3页 Journal of Bengbu Medical College
关键词 肿瘤 生促红素人肝细胞 酪氨酸蛋白激酶受体 综述
分类号 R73 [医药卫生—肿瘤]
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参考文献29

  • 1Yarden Y, Ullich A. Growth fator receptor tyrosine kinase [J]. Annu Rev Biochem, 1988,57:443-478.
  • 2Lindberg RA, Hunter T. cDNA cloning and characterization of Eck, an epithelial cell receptor proteintyrosine kinase in the eph/Eck family of protein kinases[J]. Mol Cell Biol, 1990,10(12):6316-6324.
  • 3Sulman EP,Tang XX,Allen C,et al. ECK, a human EPHrelated gene, maps to 1 p36. 1, a common region of alteration in human cancers [J]. Genomies, 1997,40(2) :371-374.
  • 4WalkerDanies J, Hess AR, Hendrix M J, et al. Differential regulation of EphA2 in normal and malignant cells [J]. Am J Patho1,2003,162(4) :1037-1042.
  • 5Stapleton D, Balan I, Pawson T, et al. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization[J]. Nat Struct Biol, 1999,6(1) :44-49.
  • 6Wu D,Suo Z,Kistensen GB,et al. Prognostic value of EphA2 and EphrinA1 in squamous cell cevrical carcinoma [J]. Gynecol 0ncol,2004,94(2) :312-319.
  • 7Zelinski DP,Zantek ND, Stewart JC, et al. EphA2 overexpression causes tumorgenesis of mammary epithelial ceils[J]. Cancer Res, 2001,61(5):2301-2306.
  • 8Zantek ND,WalkerDaniels J, Stewart J, et al. MCFIOANeoST: a new cell system for studying cellECM and cellcell interactions in breast cancer[J]. Clin Cancer Res, 2001,7(11) : 3640-3648.
  • 9WalkerDaniels J, Riese DJ, Kinch MS. cCbldependent EphA2 protein degradation is induced by ligand binding[J]. Mol Cancer Res ,2002,1(1) :79-87.
  • 10Wong A, Lamothe B, Lee A, et al. FRS2 alpha attenuates FGF receptor signaling by Grb2mediated recruitment of the ubiquitin ligase Cbl [J]. Proc Natl Acad Sci USA ,2002,99(10) :6684-6689.

二级参考文献50

  • 1Walker-Daniels J, Coffman K, Azimi M et al. Overexpression of the EphA2 tyrosine kinase in prostate cancer. Prostate, 1999, 41 : 275.
  • 2Zelinski D P, Zantek N D, Stewart J C et al. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res, 2001, 61 : 2301.
  • 3Carles-Kinch K, Kilpatrick K E, Stewart J C et al. Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior. Cancer Res, 2002, 62 : 2840.
  • 4Byrne R R, Shariat S F, Brown R et al. E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup. J Urol, 2001, 165 : 1473.
  • 5Zantek N D, Azimi M, Fedor-Chaiken M et al. E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth Differ, 1999, 10 : 629.
  • 6Orsulic S, Kemler R. Expression of Eph receptors and ephrins is differentially regulated by E-caherin. J Cell Sci, 2000, 113 : 1793.
  • 7Walker-Daniels J, Riese D J, Kinch M S. c-Cbl-dependent EphA2 protein degradation is induced by ligand binding. Mol Cancer Res, 2002, 1 : 79.
  • 8Pratt R L, Kinch M S. Activation of the EphA2 tyrosine stimulates the MAP/ERK kinase signaling cascade. Oncogene, 2002, 21 : 7690.
  • 9Zeng G, Hu Z, Kinch M S et al. High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia. Am J Pathol, 2003, 163 : 2271.
  • 10Yin BW, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J Biol Chem, 2001, 276(29) :27 371.

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蚌埠医学院学报
2011年 第1期

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