COX-2抑制剂联合放疗对人乳腺癌裸鼠移植瘤作用的研究

Effects of COX-2 inhibitor combined with radiotherapy on xenograft tumor of breast cancer in nude mice

目的观察环氧化酶-2(COX-2)抑制剂塞来昔布联合放疗对人乳腺癌MDA-MB-231细胞裸鼠移植瘤生长的影响。方法建立人乳腺癌裸鼠移植瘤模型,观察塞来昔布联合放疗治疗后裸鼠移植瘤的生长情况,测定移植瘤中COX-2、血管内皮生长因子(VEGF)的表达情况。结果塞来昔布联合放疗治疗后移植瘤的体积和重量减小(P<0.01),COX-2、VEGF表达下降(P<0.05)。结论塞来昔布联合放疗能抑制人乳腺癌裸鼠移植瘤的生长。

Objective To study the effects of COX-2 inhibitor combined with radiotherapy on xenograft tumor of breast cancer in nude mice.Methods To establish the breast cancer xenograft tumor modle in nude mice,and treated the tumor mice with radiotherapy combined celecoxib,then to detect the expression of COX-2,vascular endothelial growth factor（VEGF）,and the growth of the xenograft tumor.Results After the treatment,the weight and the volume of the xenograft tumor decreased significantly（P0.01）,the expression of COX-2 and VEGF decreased significantly（P0.05）.Conclusion Radiotherapy combined celecoxib can significantly inhibit the growth of xenograft tumor.