中国南北方强直性脊柱炎患者临床特点对比分析——附807例报告

Comparative analysis of clinical features of patients from the south and north China with ankylosing spondylitis

目的:对比分析中国南北方AS患者临床特点的异同,探讨各种因素对疾病的影响。方法:收集AS病例共807例,以籍贯为分组依据,秦岭-淮河为界区分南北方组,总结南北方两组患者的临床特点,包括起病年龄、病程、家族史、首发部位、累及关节、伴随症状、用药情况及个人生活习惯等。结果:两组患者的年龄、性别、起病年龄、病程、家族史、累及各关节部位的比例、眼炎史均无明显差异(P>0.05);南方组以中轴关节起病和有饮酒习惯的患者比例高于北方组(P<0.05);北方组以外周关节起病、腊样指(趾)症状和有吸烟习惯的患者比例高于南方组(P<0.05);南北方组患者的用药习惯有差异,北方组使用柳氮磺吡啶、中药的比例显著高于南方组(P<0.05),两组使用NSAID及生物制剂的比例比较差异无统计学意义(P>0.05)。结论:南北方AS患者的初步临床特点分析具有差异,值得进一步扩大调查和寻找原因。

Objectives： To analyze the clinical features of patients from the south and north China with ankylosing spondylitis （AS）, and to discuss the impact of these factors on disease. Methods： Information of 807 patients with AS were collected, and grouped according to birthplace. Patients with birthplace in the south and north of Qinling-Huaihe River were assigned into south group and north group, respectively. Clinical features, including the age of disease onset, duration, family history, onset joints, associated symptoms, medication history and living habits of these patients were analyzed. Results： There was no significant difference in age, sex, age of disease on- set, duration, family history, joints involved and uveitis prevalence between the two groups （P 〉 0.05 ）. Signifi- cantly more patients with onset of axial joints and alcohol consumption habit were observed in south group, while significantly higher prevalence of onset of peripheral joints, sausage-like swelling digits and smoking habit was found in north group （P 〈 0. 05 ）. Significantly different usage of drugs was observed between groups, while traditional Chinese medicine and sulfasalazine were more popularly used in the north group （P 〈 0. 05 ）. However, no significant difference was revealed in usage of non-steroidal anti-inflammatory drugs and biological agents between groups. Conclusions： There are some differences of the clinical features between patients with AS from the south and north China, thus further study will be necessary.