静滴阿奇霉素致过敏性休克60例文献分析

Literature Analysis of 60 Cases of Anaphylactic Shock Induced by Azithromycin Intravenous Injection

目的:探讨静脉滴注阿奇霉素引起过敏性休克的临床表现、特点和预防措施,为临床监测其不良反应并避免严重不良后果提供参考。方法:利用"中文全文期刊数据库"、"中文科技期刊全文数据库"等检索工具,对1999～2010年国内医药学期刊发表的文献进行检索,共检索到静滴阿奇霉素引起过敏性休克的文献44篇,涉及病例60例。结果:阿奇霉素引起过敏性休克未见明显的性别差异,可发生于各个年龄组,男女各30例;休克多发生在用药后20 min内(86.7%);治疗后58例康复(96.7%),2例死亡(3.3%)。结论:临床静滴阿奇霉素,应注意密切监测,一旦发生过敏性休克,应及时抢救,避免出现严重后果。

Objective：To study the clinical manifestations, characteristics and preventive measures of azithromytin-induced anaphylactic shock, and to provide references for the ADR monitoring and the prevention of serious incidents. Method：The literatures between 1999 and 2010 were searched from Chinese Journal Full-text Database and Chinese Science and Technology Journal Full-text Database, 44 articles involved 60 cases of anaphylactic shock induced by azithromycin intravenous injection were collected and analyzed. Result：No significant difference between male and female was found （30 cases vs 30 cases） ; most of anaphylactic shock occurred within 20 minutes after administration （58.3%） ; 58 cases recovered （96.7%） and 2 cases died （3.3%） after treatment. Conclusion：It was necessary to conduct a close momitoring of azithromycin intravenous injection, and an instant treatment on the allergic shocks was decisive for prevention of serious incidents.