382株耐甲氧西林金黄色葡萄球菌的耐药性分析

Analysis of methicillin-resistant Staphylococcus aureus to commonly uscd antibiotics

目的了解本地区耐甲氧西林金黄色葡萄球菌的临床感染现状和耐药性，提供临床参考。方法采用法国梅里埃葡萄球菌鉴定试剂盒和ATBExpression仪鉴定细菌的种类，用纸片扩散法进行药敏试验。结果2007～2009年共分离金黄色葡萄球菌784株，其中耐甲氧西林金黄色葡萄球菌（（MRsA）395株，检出率50．4％。全部金葡菌株对万古霉素和利奈唑胺都敏感，MRSA株对青霉素、红霉素、环丙沙星、左氧氟沙星、克林霉素、替考拉宁和复方新诺明的耐药率分剐为100％、94．4％、87．1％、80．0％、86．8％、71．6％和44．1％。结论MRSA的检出比率较高，耐药性严重。呈多重耐药，临床应高度重视对MRSA及其耐药性的检测，以帮助合理用药。

Aim To analyze the incidence and resistance of methicillin-resistant Staphylococcus aureus （MRSA） to common used antibiotics. Methods The bacterial strains were automatically identified with French Merieux aureus identification kits and ATB Expression,and then the antibiotic resistances were tested by standard Kirby-Bauer method. Results A total of 765 strains were isolated during 2007-2009,in which 382 were MRSA （49.9%）. All isolates were susceptible to vancomycin and hnezolid. The resistant rate of the isolates of MRSA to penicillin, erythromycin, ciprofloxacin, levofloxacin,clindamycin,teicoplanin,and cotrimoxazole were 100% ,96.9% ,89.8% ,83.9% ,88.0% ,74.2% and 43.0%. Conclusions The isolation rate of MRSA increased significantly. For effective supervision and control of Staphylococcus aureus infection and dealing with multiple resistance,susceptibility survey of MRSA to antibiotics be performed to guide rational use of clinical drugs.