院内综合康复训练对精神分裂症患者认知功能的影响

Effect of in-hospital comprehensive rehabilitation training on schizophrene＇s cognitive function

目的探讨院内综合康复训练对精神分裂症患者认知功能的影响。方法将80例恢复期精神分裂症患者随机分为研究组40例（脱落2例）和对照组40例（脱落1例），两组均接受常规治疗和护理，研究组在常规治疗护理的基础上参加生活行为技能训练、药物管理技能训练、职业技能训练和社会交往能力训练等院内综合康复训练，观察12周，于训练前后分别采用韦氏成人记忆表修订本（WMS—RC）、精神分裂症阳性症状量表和阴性症状量表（PANSS）、住院患者观察量表（NOSIE）测定，比较两组认知功能的变化情况。结果入组前两组WMS—RC、PANSS、NOSIE因子评分的比较差异均无统计学意义（P〉0．05）；训练后12周两组WMS—RC因子中计算评分（15．09±1．57VS13．36±1．55，t=3．005，P=0．04）、数字广度评分（13．32±1．68vs12．08±1．79，t=3．124，P=0．003）、数字符号评分（8．17±2．21vs8．24±1．41，t=3．212，P=0．003）、因子总分（32．79±6．14vs29．78±4．58，t=3．412，P=0．001）、记忆商数评分（116．25±3．94vs112．72±3．07，t=4．382，P=0．000）比较差异均有统计学意义；PANSS因子（除阳性症状外）、NOSIE因子评分比较差异均有统计学意义（P〈0．01或P〈0．05）。结论院内综合康复训练能改善精神分裂症患者认知功能。

Objective To investigate the effect of in-hospital comprehensive rehabilitation training schizophrene＇s cognitive function. Methods 80 schizophrenic patients were randomly divided into study group （n = 40） and control group（ n =40）. Both groups received conventional treatment and care, the study group also received inhospital comprehensive rehabilitation training such as life skills training, medication management skills training, vocational skills training and social communication training for 12 weeks. Their cognitive function was measured with Wechsler Adult Memory （Revised） （ WMS-RC）, Positive and Negative Symptom Scale （PANSS）, Nurses＇ Observation Scale for Inpatient Evaluation （NOSIE） before and after the training, respectively, and changes in cognitive function were compared. Results There was no statistically significance in WMS-RC, PANSS, NOSIE scores between the study group and the cantrol group before training. There was statistically significance in WMS-RC ,Calculation scores（ 15.09 ± 1.57 vs 13.36 ±1.55 ,t =3. 005 ,P = 0. 04）, dtgit span scores （ 13.32 ±1.68 vs 12.08 ±1.79,t = 3. 124,P = 0. 003 ）, number sign （8. 17 ±2.21 vs 8.24 ±1.41 ,t = 3. 212,P = 0. 003） ,total sares（32.79 ±6. 14 vs 29.78 ±4.58,t = 3. 412,P = 0. 001 ）, memory quotient sares （116.25 ±3.94 vs 112.72 ±3.07,t = 4. 382,P = 0. 000）between the two groups ccfter 12 weeks; There was statistically significamce in PANSS, NOSIE scores between the study group and the control group after training 12 weeks. Conclusions In-hospital comprehensive rehabilitation training can improve schizophrene＇s cognitive function.