感染后咳嗽患儿血微量元素分析与黄芪注射液联合甘草合剂治疗研究

Analysis of Trace Elements of Blood of Children's Post-infectious Cough and Combined Therapy of Astragalus and Licorice Mixture

分析儿童感染后咳嗽的临床特点以及与外周血微量元素的关系,观察黄芪注射液联合甘草合剂治疗儿童感染后咳嗽的疗效。对自2006年1月至2008年6月在德州市妇幼保健院儿科门诊治疗的75例感染后咳嗽患儿行外周血微量元素测定,与40例健康小儿微量元素对比,并将75例患儿随机分为两个治疗组进行临床观察:实验组39例,口服黄芪注射液和甘草合剂联合治疗;对照组36例,口服阿奇霉素治疗;对比两组疗效,并在治疗前后行肝肾功检查,观察有无肝肾损害。75例患儿外周血铁、锌、镁均有不同程度的降低。实验组疗效优于对照组,治愈率分别为92.31%和75%,统计学处理χ2=4.17,P<0.05。治疗前后两组均未出现肝肾功损害。感染后咳嗽发病可能与患儿血中微量元素铁、锌、镁降低有关,黄芪注射液联合甘草合剂治疗儿童感染后咳嗽安全有效。

To analyse the clinical features of children＇s post-infectious cough and the relationship between trace elements and the peripheral blood, and observe the treatment of combined therapy of Astragalus and Licorice mixture. We made determination of trace elements in peripheral blood of 75 cases of post-infectious in children that treated in pediatric outpatient of Maternal and Child Health Hospital of Dezhou from January 2006 to June 2008. We compared the trace elements of patients with 40 healthy children＇s. Our 75 cases were randomly divided into two treatment groups in clinical observation. Experimental group, 39 patients with oral combination therapy Astragalus and licorice mixture; the control group, 36 pa- tients with oral Azithromycin; Compared two groups, checked the liver and kidney function before and after treatment,and observe whether the liver and kidney had been damaged. 75 cases of peripheral blood iron, zinc and magnesium were significantly lower. The efficacy of the experimental group than the control group, the cure rate were 92.31% and 75 %, statistically X^2 =4. 17 ,P〈0. 05. Before and after treatment both groups had no damage to liver and kidney function. The incidence of infection may be associated with cough and trace elements in children with the decreased blood iron, zinc, magnesium. Combined therapy of Astragalus and Licorice mixture were safe and effective.