铜绿假单胞菌Ⅰ类整合子及耐药基因分析

Analysis of Drug Resistance Genes Associated with Class Ⅰ Integron in Pseudomonas Aeruginosa

铜绿假单胞菌是临床上重要的院内感染菌,对多种抗生素耐药。整合子是能捕获并整合外源耐药基因盒,并使之表达的DNA元件。通过整合子水平转移的方式极大地加速了耐药基因在同种及不同种属之间的传播,造成细菌的耐药以至多重耐药问题日益严重。

Pseudomonas aeruginosa has emerged as an important nosocomial bacterial pathogen and it is very often resistant to most of the antimicrobial agents. Integrons are novel DNA elements, which can capture and incorporate gene cassettes embedded in exogenous by site--specific recombination. Meanwhile, they are able to convent gene cassettes to functional genes by ensuring their correct expression. The horizontal transfer of integrons within and between microbial genera has speeded up emergence of novel antibiotic resistance gene. To date, the mechanism of resistance to antibiotics is becoming exceedingly complex. Therefore, intensive research leading to greater understanding is imperative.