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GBR联合PRF修复根尖周囊肿骨缺损的临床观察 被引量:4

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摘要 引导骨再生术(guided bone regeneration,GBR)是利用膜的屏障作用促使成骨性细胞优先向骨缺损区迁移、生长,进而实现骨再生和修复目的的手术。富血小板纤维蛋白(platelet rich fibrin,PRF)为自体全血离心产物,富含生长因子并可通过局部缓慢释放生长因子促进组织愈合和骨再生。有研究表明:在GBR中引人生长因子可显著地加速细胞生长和分化。本文作者采用GBR联合PRF修复根尖周囊肿骨缺损1例,疗效满意,现报道如下。
出处 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2011年第2期295-295,共1页 Journal of Jilin University:Medicine Edition
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同被引文献21

  • 1Anilkumar K, Geetha A, Umasudhakar, et al. Platelet-rich- fibrin: A novel root coverage approach. J Indian Soe Periodon- tol, 2009,13( 1 ) :50-54.
  • 2Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Leu- coeyteactivation: a new feature for platelet concentrates. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006,101(3): e51-e55.
  • 3He L, Lin Y, Hu X, et al. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect ofproliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009, 108 (5): 707 -713.
  • 4Dohan Ehrenfest DM, Diss A, Odin G, et al. In vitro effects of Choukroun's PRF (platelet-rich fibrin) on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009,108(3):341-352.
  • 5Dohan Ehrenfest DM, Doglioli P, de Peppo GM, et al. Choukroun's platelet-rich fibrin (PRF) stimulates in vitro proliferation and differentiation of human oral bone mesenchymal stem cell in a dose-dependent way. Arch Oral Biol, 2010,55(3) : 185-194.
  • 6Huang FM, Yang SF, Zhao JH, et al. Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. J Endod, 2010,36(10) : 1628-1632.
  • 7Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in chronic periodontitis subjects with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol, 2011,82(12) : 1705-1712.
  • 8Sharma A, Pradeep AR. Autologous platelet rich fibrin in the treatment of mandibular degree ]I furcation defects: randomized clinical trial. J Periodontol, 2011,82 (10) : 1396- 1403.
  • 9Nkenke E, Schlegel A, Schultze-Mosgau S, et al. Theendoscopically controlled osteotome sinus floor elevation: a preliminary prospective study. Int J Oral Maxillofac Implants, 2002,17(4) :557-566.
  • 10Jang ES, Park JW, Kweon H, et al. Restoration of peri- implant defects in immediate implant installations by Choukroun platelet-rich fibrin and silk fibroin powder combination graft. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010,109 (6) :831-836.

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