泉州地区女性人乳头状瘤病毒感染与宫颈病变的相关性探讨

Relationship between human papilloma virus infection and cervical lesion of women in Quanzhou

目的探讨泉州地区女性人乳头状瘤病毒(HPV)的感染率及型别分布特点。方法采用导流杂交基因芯片法对泉州地区4769例女性进行HPV分型检测,其中562例同时做液基细胞学(TCT)检测。结果筛查人群HPV的总感染率为23.6%,感染率最高的型别为HPV16,为26.6%;其次为HPV52、11、58、6、18,分别为18.8%、16.2%、13.4%、12.2%、8.8%;各年龄段HPV的感染率差异有统计学意义(χ2=36.486,P<0.01),82例宫颈癌患者HPV感染率为86.6%,显著高于宫颈炎患者(2χ=110.414,P<0.01)和健康体检者(2χ=157.925,P<0.01);宫颈癌患者HPV感染以HPV16型为主,其次为HPV18型。结论不同人群HPV感染率差异有统计学意义(P<0.01),HPV感染与宫颈病变及宫颈癌的发生密切相关,HPV检测是筛查宫颈癌的有效辅助方法。

OBJECTIVE To investigate the infection rate and subgenotypes distribution of human papilloma virus（HPV） in women of Quanzhou.METHODS A total of 4769 women were checked for 21 subtypes of HPV by flow-through hybridization and gene chip technology.Thinprep Cytology Test was also detected in 562 patients.RESULTS The positive rate of HPV in 4769 women was 23.6%.HPV 16 was the most common type,and the other common types,in descending order of frequency,were 52,11,58,6 and 18,the infection rates of which were in turn 18.8%、16.2%、13.4%、12.2%、8.8%.There was significant difference in HPV positive rates among the investigated age group（χ2=36.486,P0.01）.The infection rate of HPV in 82 patients（86.6%） was significantly higher than that in women with cervical erosion（P0.01） or normal healthy women（P0.01）.There was a significant difference between cervical erosion group and normal healthy group as well（P0.01）.HPV 16 infection was the most common type in cervical cancer patients,accounting for 26.6% followed HPV 18.CONCLUSION The HPV positive rates among different groups are significantly different（P0.01）.High risk HPV infection is closely related with the cervical lesion as well as cervical cancer.HPV detection is a valuable technique for cervical cancer screening.