2009年阿奇霉素临床应用分析

Clinical application of azithromycin in 2009

目的分析2009年医院阿奇霉素临床的应用。方法回顾性分析163份病历资料,163例患者均有感染且使用阿奇霉素治疗。结果阿奇霉素临床主要用于治疗呼吸道感染和泌尿道感染,分别占69.3%和16.6%;共分离出163株病原菌,以肺炎克雷伯菌、金黄色葡萄球菌和肺炎链球菌为主,分别占28.2%、17.8%和14.7%;163株病原菌对阿奇霉素的敏感株有146株,敏感性为89.6%;163株病原菌清除141株,未清除13株,部分清除0株,替换9株,细菌清除率为86.5%;163例患者有6例出现胃肠道反应,4例出现皮肤过敏性反应,不良反应发生率为6.1%。结论阿奇霉素临床主要用于治疗呼吸道感染和泌尿道感染,对呼吸道感染所致多种病原菌具有较好的清除效果。

OBJECTIVE To analyze the clinical application of azithromycin in 2009.METHODS The clinical data of 163 cases treated with azithromycin were retrospectively analyzed.RESULTS Azithromycin were mainly used for the treatment of respiratory tract infection and urinary tract infection,accounting for 69.3% and 16.6%,respectively.A total of 163 strains of pathogens were isolated,and Klebsiella pneumoniae,Staphylococcus aureus,and Streptococcus pneumoniae were the main pathogens,accounting for 28.2%,17.8%,and 14.7%,respectively.The drug sensitivity rate was 89.6%.141 strains were removed,unremoved（13 strains）,partly removed（0） and replaced（9 strains）,with the bacterial clearance rate of 86.5%.6 cases occurred to the gastrointestinal side effects,4 cases occurred to the allergic skin reactions,and the incidence rate of adverse reaction was 6.1%.CONCLUSION Azithromycin is mainly used for the treatment of respiratory tract infection and urinary tract infection,and it has better efficiency on a variety of pathogens.