2005-2009年医院感染铜绿假单胞菌的临床分布及耐药性分析

Clinical distribution and antibiotic resistance of pseudomonas aeruginosa causing nosocomial infection during 2005-2009

目的分析2005-2009年医院感染铜绿假单胞菌的临床分布和耐药性特点,为控制铜绿假单胞菌(PAE)感染提供依据。方法收集2005-2009年临床分离的铜绿假单胞菌1428株,用K-B纸片扩散法进行药敏试验,统计分析药敏资料。结果 5年中,铜绿假单胞菌在革兰阴性杆菌中的检出率为23.75%,以ICU的检出率最高,占35.08%,各类标本中以痰和咽拭子的检出率最高,占86.06%,其对多种药物的耐药性有上升趋势。结论铜绿假单胞菌检出率较高,耐药性有上升趋势,应规范临床用药,并加强实验室监测。

OBJECTIVE To investigate the clinical distribution and antibiotic resistance of nosocomial infection Pseudomonas aeruginosa（PAE） during 2005-2009 to provide reference for the clinical treatment of infection with PAE.METHODS A total of 1428 PAE isolates were collected during 2005-2009.Kirby-Bauer method was used for antimicrobial susceptibility.The data was analyzed.RESULTS The isolating rate of PAE from Gram-negative bacteria was 23.75% in the five years.The detection rate of PAE was highest in ICU with 35.08% and the detection rate of PAE from sputum and throat swab was the highest among all kinds of specimens,accounting for 86.06%,the drug resistance of PAE to several antibiotics kept an upward tendency.CONCLUSION The detection rate of PAE is high and the antibiotic resistance is continuously increasing.It should standardize the rational use of antibiotics and strengthened the monitoring in laboratory.