基层医院铜绿假单胞菌的分布及耐药性分析

Clinical distribution and drug resistance of pseudomonas aeruginosa in grass-roots hospitals

目的探讨基层医院培养的铜绿假单胞菌对常用抗菌药物的耐药性,为临床合理使用抗菌药物提供试验依据。方法采用K-B法对医院感染性标本中分离的234株铜绿假单胞菌进行14种抗菌药物的体外药敏试验结果两年来从临床各类标本中共分离出铜绿假单胞菌234株,其中尿液标本占43.2%,痰液标本占20.1%,脓液和分泌物标本占17.9%,穿刺液标本占12.0%;铜绿假单胞菌对常用抗菌药物的耐药率以亚胺培南和美罗培南为最低,分别为2.1%、1.7%;其他耐药率较低的还有头孢哌酮/舒巴坦(13.2%)、哌拉西林/他唑巴坦(13.2%)、阿米卡星(20.1%)等;而氨曲南、头孢噻肟、左氧氟沙星、环丙沙星耐药率均>50.0%。结论医院感染铜绿假单胞菌具有多药耐药性,需加强监测与控制。

OBJECTIVE To approach the drug resistance of Pseudomonas aeruginosa in grass-root hospitals to commonly used antibiotics and provide the experimental evidence for reasonably clinical choice of antibiotics.METHODS The in vitro drug susceptibility tests to 14 kinds of antibiotics were performed in 234 PAE isolates from infective specimen by K-B methods.RESULTS The drug resistant rates of imipenem（2.1%） and meropenem（1.7%） were the lowest.The drug resistant rates of PAE cefoperazone/sulbactam（13.2%）,piperacillin/tazobactam（13.2%） and amikacin（20.1%） were lower,of aztreonea,cefotaxime,levofloxacin and ciprofloxacin were all above 50.0%.The multi-drug resistant status of PAE existed.CONCLUSION The multiple drug resistance exists in nosocomial infections caused by PAE.The monitoring and controlling should be strengthened.