支原体属对抗菌药物的敏感性及感染后疗效研究

Sensitivity of mycoplasma to antibiotics and clinical efficacy after treatment

目的探讨支原体属对抗菌药物的敏感性及临床用药后疗效情况,指导临床合理用药。方法取医院内支原体属阳性标本120例,观察其感染情况及对抗菌药物敏感情况,并从中选取20例复诊患者进行观测。结果 120例支原体阳性标本中,解脲脲支原体(Uu)、人支原体(Mh)及Uu+Mh混合感染的阳性率分别为66.67%、4.16%、29.17%,女性感染率明显高于男性;支原体属对米诺环素、多西环素敏感性最高,对罗红霉素耐药性最高,混合感染标本中有2株对9种抗菌药物全耐药;复诊患者对9种抗菌药物的耐药性明显提高。结论支原体属耐药菌株常见,由于现在社会抗菌药物滥用现象严重,临床更应谨慎用药,疗效以临床症状改善为主。

OBJECTIVE To explore the sensitivity of mycoplasma to antibiotics and clinical efficacy after treatment in order to direct the clinical reasonable medication.METHODS The infection situation and antibiotic sensitivity of 120 cases of mycoplasma-positive samples obtained in the hospital were analyzed,and 20 cases re-examination patients were selected to be detected.RESULTS In 120 cases of mycoplasma-positive samples,the positive rates of Uu,Mh infection and Uu＋Mh mixed infection were 66.67%,4.16% and 29.17%,respectively.And the positive rate of female was higher than that of male.The results of drug susceptibility showed that the mycoplasma was sensitive to minocycline and doxycycline but resistant to roxithromycin.Two cases of mixed infection samples were resistant to all 9 antibiotics.The drug resistance to 9 kinds of antibiotics in re-examination patients was significantly increased.CONCLUSION Resistant strains of mycoplasma are common.Because the abusement of antibiotics is serious recently,the clinics should medicateantibiotics more cautiously to improve efficacy in the clinical work.