摘要
目的探讨曲美他嗪治疗冠心病心绞痛的疗效及安全性。方法选择72例冠心病心绞痛患者随机分为2组,治疗组40例,应用硝酸酯类、抗血小板制剂等传统药物治疗合并曲美他嗪20mg,口服,每日3次。对照组32例为常规用药,连续观察2个月。对照观察两组患者心绞痛改善程度,心电图变化及血压、心率的变化。结果临床总有效率治疗组明显高于对照组,有显著性差异(P<0.001)两组的血压、心率变化无明显差异(P>0.05)。结论曲美他嗪作为一种常用的心肌能量代谢药物,对改善心肌缺血,改善心绞痛患者运动能量及临床症状,疗效确切,安全可靠。
Objective To explore the effect of trimetazidine on angina.Methods 72 patients with angina were divided into two groups randomly,The treatment group（40 cases） was given trimentazidine（20mg po,tid） based on the routine treatment（nitrates,antiplatelet drugs and so on）,the control group（32cases） was given routine treatment.Two months later,the difference between two groups in relieved degree of angina,change of ECG,blood pressure and heart rate was observed.Results The total clinic effectivitv in treatment group was higher than the control group（P0.001）,there was no difference in change of blood pressure heart rate between two group.Conclusion Trimetazidine has exact effect on antimyocardial ischemia and can improve exercise tolerance,clinic symptom of patients with angina.
出处
《中国医药指南》
2011年第10期19-19,34,共2页
Guide of China Medicine
关键词
曲美他嗪
心绞痛
心肌缺血
Trimetazidine
Angina
Myocardial ischemia
