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酮内酯类抗生素噻霉素研究进展

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摘要 噻霉素作为酮内酯类的第二个药物,其对于多种常见的呼吸道病原菌,包括对β-内酰胺类、大环内酯类类耐药的菌株均具有良好的的抗菌活性,因而受到广泛的关注。1作用机制噻霉素的抗菌谱与红霉素相似。可与细菌核糖体50s亚单位的23s核糖体Ⅱ区结构的核苷酸结合,抑制细菌蛋白质的合成,并阻止其翻译和装配。
作者 杨明 周玥
出处 《中国医药指南》 2011年第10期44-44,共1页 Guide of China Medicine
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