Pim-1蛋白激酶在肺癌组织中的表达及临床相关性的研究

Expression of PIM-1 kinase in human lung cancer and its clinical significance

目的探讨Pim-1在肺癌中的表达和临床意义。方法免疫组织化学方法检测38例肺癌组织标本和12例正常肺组织标本中的Pim-1蛋白激酶的表达情况,结果分为阴性、弱阳性、阳性和强阳性。对肺癌组与正常对照组间的Pim-1表达情况完成差别性检验,并通过差别性检验以及Logisitc回归分析探讨与肺癌患者Pim-1表达相关的临床因素。结果 Pim-1在肺癌标本的阳性率为55.26%(21/38),正常肺组织的阳性率是17.00%(2/12),Pim-1在肺癌组织的表达高于正常肺组织(P<0.05)。Pim-1蛋白水平表达随肺癌的TNM分期增高而增强,随肿瘤直径的增高而增强,有明显的正相关性。结论 Pim-1的高表达与肺癌具有密切关系,Pim-1表达水平与肺癌的TNM分期和肿瘤大小呈正相关,由此提示:Pim-1表达可能与肿瘤病程进展有关,有可能作成为肺癌的靶向治疗的新靶点。

【Objective】 Aim of this study was to investigate the expression of Pim-1 kinase in tissue of human lung cancer and its relationship to histological type,grade,differentiation and metastasis.【Methods】 Thirty-eight pathological primary lung cancer specimens and 12 cases of normal lung were observed by using immunohistochemical technique.【Result】 The positive expression of Pim-1 in lung cancer and normal lung was 55.26% and 17.00%,respectively.A significant difference was identified（P 0.05）.Compared with those cases in different TNM staging,there was positive correlation.【Conclusion】 The high expression of Pim-1 is closely related with lung cancer,the expression of Pim-1 and TNM staging of lung cancer,tumor size are positively correlated.It is suggested that Pim-1 may be associated with the degree of malignancy and can be a new target point for lung cancer targeted therapy.