肝储备功能测定在肝癌介入治疗中的应用研究

Application of liver reserve function determination in hepatic cancer interventional chemoembolization

目的探讨用吲哚氰绿潴留率(ICGR15)评估原发性肝癌(HCC)患者介入化疗栓塞前肝储备功能的临床价值。方法 76例HCC患者介入化疗栓塞前测定ICGR15,并根据结果将患者分为3组,同时对所有患者进行Child-Pugh评分。分析介入化疗栓塞后3组间ICGR15改变的差异。结果介入化疗栓塞后3组间并发症的发生率差异具有显著性(P<0.05),介入化疗栓塞前不同的Child-Pugh分级间并发症的发生率差异无显著性(P>0.05)。结论与Child-Pugh分级相比,ICGR15⑹能够更准确地评估介入化疗栓塞前肝储备功能。

【Objective】 To evaluate the clinical significance of determining the liver reserve function by estimating the retention rate of indocyanine green at fifteen minutes（ICGR15） before interventional chemoembolization for primary hepatocellular carcinoma（HCC）.【Method】 Seventy-six patients with HCC were enrolled in this study.Before interventional chemoembolization ICGR15 and Child-Pugh classification were estimated in all patients.Based on the ICGR15,the patients were divided into three groups.The occurrence of postoperative hepatic dysfunction and the difference in the hepatic function changes between three groups were analyzed.【Results】 After interventional chemoembolization the occurrence of hepatic dysfunction were significantly different between three groups divided by ICGR15 test（P 0.05）.The two groups divided by Child-Pugh classification was no significant difference（P 0.05）.【Conclusion】 The hepatic reserve function in HCC patients can be more precisely evaluated by ICGR15 than by Child-Pugh classification.