新疆蓝刺头中一个新的过氧环状化合物

Natural Cyclic Peroxide Echinobithiophene A with Anti-microbial from Echinops ritro L.

从新疆蓝刺头中分离出一个新的含六元过氧环的二联噻吩类化合物(3R,4R,5S)-3-[(2,2'-bithio-phen)-5-yl]-1,2-dioxane-4,5-diol,命名为Echinobithiophene A(1).通过2D NMR谱、旋光和13C NMR谱等计算方法确定该化合物的绝对构型为3R,4R,5S.活性测试结果表明,该化合物对S.aureus ATCC2592,E.coli ATCC25922和C.albicans ATCC2002等3种菌株具有较强的抗菌活性,其最小抑菌浓度(MIC)值分别为75,37.5和75μg/mL.

The genus Echinops（Compositae） consists of ca.120 species in the world.This genus is represented by 17 species mainly distributed in northwestern area of China.E.ritro L.has only been found in Xinjiang and is used as a remedy for different ailments in Uighur Pharmacopeia instead of E.grijissi Hance.Echinobithiophene A（1）,a new peroxide bithiophene with a six-membered ring,was isolated from the ethyl acetate fraction of Echinops ritro L.,and its structure was identified by spectral analysis including 2D NMR,and comparison of optical rotation values and chemical shifts of 13C NMR between the predicted and experimental data.Compound 1 showed significant anti-microbial activity.