EMS1蛋白在食管鳞状细胞癌组织中的表达及其临床意义

The expression and clinical significance of EMS1 in esophagus aquamous cell carcinoma

目的探讨EMS1(mammary tumour and squamous cell carcinoma-associated gene 1)蛋白在食管鳞状细胞癌组织中的表达及其临床意义。方法应用免疫组织化学SP法检测74例食管鳞状细胞癌组织中EMS1蛋白的表达,分析其与临床病理因素的关系。结果 EMS1蛋白定位于细胞胞浆及细胞膜下或胞浆皮质区。EMS1蛋白在食管鳞状细胞癌组织中的表达率(74.3%)明显高于其在癌旁组织中的表达率(31.1%),差异有显著性(P<0.01)。EMS1蛋白表达与食管鳞状细胞癌的浸润深度、淋巴结转移及临床TNM分期密切相关(P<0.05或P<0.01)。而与患者的年龄、性别、肿瘤大小及组织分化程度无关(P>0.05)。结论 EMS1蛋白是食管鳞状细胞癌发展、侵袭和转移的重要生物标志物。对判断食管鳞状细胞癌的淋巴结转移和其生物学行为以及临床预后具有较高的临床应用价值。

【Objective】 To study the expression of EMS1 protein in esophagus squamous cell carcinoma（ESCC） and its clinical significance.【Methods】 The expression of EMS1 protein was detected in 74 surgical specimens of ESCC using an immunohistochemistry SP method.The correlations of the expression with clinicopathological parameters of ESCC were analyzed.【Results】 The positive EMS1 staining was located in cytoplasm and cell membrane.The positive rate of EMS1 expression was significantly higher in the ESCC tissues than that in the normal esophageal squamous tissues（74.3% vs 31.1%,P 0.01）.The EMS1 protein expression significantly correlated with the TNM stages and lymph node metastasis in ESCC（P 0.01）,whereas had no correlations with sex,age,tumor differentiation level,and diameter（P 0.05）.【Conclusion】 The results suggested that the overexpression of EMS1 protein plays important roles in the progression of ESCC.EMS1 protein is a valuable marker to predict the biological behavior,metastasis status,and prognosis in ESCC.