甲钴胺联合加巴喷丁治疗糖尿病痛性神经病变的临床观察

Clinical effect of Mecobalamine and Gabapentin on diabetic painful sensory neuropathy

目的观察甲钴胺联合加巴喷丁治疗糖尿病痛性神经病变的疗效。方法随机将47例糖尿病痛性神经病变的患者分为两组,治疗组25例应用甲钴胺联合加巴喷丁观察疼痛缓解情况;对照组22例进行常规治疗。疗程3周,观察治疗前后临床症状,并行肌电图检查。结果甲钴胺联合加巴喷丁组有效率显著高于对照组(P<0.05)。结论甲钴胺联合加巴喷丁可明显改善糖尿病痛性神经病变。

【Objective】 To observe the effect of Mecobalamine and Gabapentin on diabetic painful sensory neuropathy（DNP）.【Methods】 47 DNP patients were randomly divided into the group treated with Mecobalamine and Gabapentin（n =25） and the control group receiving conventional therapy（n =22）.After 3 weeks the symptom of all of patients was compared with that of pretherapy.Furthermore the electromyogram（EMG） was measured in every patient.【Result】 The effective power in the treatment group was significantly higher than the control group＇s（P 0.05）.【Conclusion】 Mecobalamine combining with gabapentin can remarkably relieve DNP.