16例重症感染甲型H_1N_1流感患者药物利用分析

Analysis on the of drugs used for severe influenza A(H_1N_1) in 16 cases of patients

目的:调查分析我院收治的16例重症甲型H1N1流感患者的药物利用情况。方法:采集16例患者病历、及用药记录中疾病诊断和药物治疗相关数据,根据WHO合理用药指标:限定日剂量(DDD)、药物利用指数(DUI)、用药例次数、人均用药费用等回顾性分析评价用药情况。结果:16例重症甲型H1N1流感患者共使用药物128种,其中大输液、抗菌药物、中成药、消化系统药物、循环系统药物,占药品种数64.3%。抗菌药物、激素使用总体合理。奥司他韦疗效确切。结论:针对甲型H1N1流感患者治疗过程中存在的不合理用药现象,迫切需要制定更规范的治疗指南,提高用药安全性与合理性。

OBJECTIVE To investigate the drug used in patients with severe influenza A（H1 N1 ）. METHODS The medical records were collected and analyzed retrospectively, according to the rational drug utilization index, including defined daily dose （DDD）, drug utilization indcx（DUI）, frequency of medication and per capita drug costs. RESULTS 128 kinds of drugs were applied to the 16 patients, including infusion fluid, antibiotics, Chinese lraditional patent medicines, digestive system agents and circulatory system agents, which accounting for 64. 33%. Hormone drugs and antibiotics were overall rationally used. Os eltamivir is effective. CONCLUSION Treatment guidelines are needed to promote the safety and rationality in drug utilization for patients with severe influenza A（ H1 N1 ）.