藏药螃蟹甲的镇痛抗炎作用

Analgesic and anti-inflammatory activities of Phlomis younghusbandii

目的研究螃蟹甲的镇痛抗炎作用。方法以螃蟹甲水提取物为研究对象,采用小鼠醋酸扭体法、热板法、耳肿胀法、足肿胀法及毛细血管通透性实验等方法来观察其镇痛抗炎作用。结果螃蟹甲水提取物能显著减少小鼠扭体反应的次数,高剂量组能明显延长热板所致的小鼠舔后足的时间,对小鼠耳肿胀及足肿胀均有显著的抑制作用,且能降低毛细血管的通透性,显著抑制醋酸所致的小鼠腹腔炎症渗出。结论螃蟹甲水提取物具有较好的镇痛抗炎活性。

OBJECTIVE To study the analgesic and anti-inflammatory effects of Phlomis younghusbandii in mice.METHODS Administered the extracts of Phlomis younghusbandii by intraperitoneal injection,the acetic-acid induced writhing times,the hot plate pain threshold,xylene-induced ear swelling and carrageenan-induced hind paw edema,and acetic acid induced the peritoneal capillary permeability in mice were observed and determined.RESULTS The water extracts of Phlomis younghusbandii could remarkably reduce the times of writhing reaction induced by acetic acid in mice and the high dose could prolong the leg-licking time in mice provoked by hot plate.It could significantly inhibit mice auricula swelling and paw edema induced by xylene and carrageenan respectively,it also reduced peritoneal capillary permeability and inflammatory peritoneal exudation induced by acetic acid.CONCLUSION The water extracts of Phlomis younghusbandii showed a certain analgesic and anti-inflammatory activities.