伊立替康在晚期胃癌中的作用与地位

CPT-11 iIn the function and position in the stomach cancer in later period

目的评价伊立替康在晚期胃癌化疗中的临床疗效及毒副作用。方法将52例晚期胃癌患者随机分为两组,A组应用伊立替康联合希罗达,B组应用伊立替康联合替加氟,均化疗2个周期以上,观察疗效及毒副作用。结果两组患者近期疗效比较,A组有效率为50%,B组有效率为46.15%,差异无统计学意义;毒副反应A组恶心、呕吐发生率、腹泻发生率较B组高,B组血小板减少较A组高(P<0.05)具有统计学意义。结论以CPT-11为基础的化疗方案对晚期胃癌有良好的疗效,且毒副反应可以耐受,CPT-11有望在晚期胃癌的治疗中起重要的作用。

Objective Evaluate CPT-11 the clinical curative effect in the stomach cancer chemotherapy and poison side effect in later period.Methods 52 later period stomach cancer the sufferer is random divided into 2 sets,The A set is applied CPT-11 Unite Xeloda,The B set is applied CPT-11 Unite ftorafur,All chemotherapy 2 periods are above,observe curative effect and poison side effect.Results Two sets of sufferers in the near future curative effect compare,the A set is efficient to is 50%,the B set is efficient for 46.15%,and the difference has no statistics to learn meaning;Poison pair the reaction A set is disgusted,vomit incidence rate,diarrhea incidence rate compare B set high,B set the blood platelets reduce compare A set high.Conclusion The CPT-11-based chemotherapy project has good curative effect to the stomach cancer in later period,and the poisonous pair reaction can bear to be subjected to,CPT-11 has the under medical treatment of the stomach cancer to hope in the later period to contain important function.