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右佐匹克隆治疗老年期失眠症的对照研究 被引量:5

Controlled trial of efficacy and safety of eszopiclone in treatment of late-life insomnia
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摘要 目的评估右佐匹克隆治疗老年期失眠症的疗效和安全性。方法符合失眠症诊断标准,年龄≥65岁患者,共入组80例,研究组40例,对照组40例,分别服右佐匹克隆(3~6 mg)或阿普唑仑(0.4~0.8 mg),共2周。用匹兹堡睡眠质量指数(PSQI)、汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)评估失眠严重程度和疗效,不良事件报告评价安全性。结果研究组有效率75.0%,对照组67.5%,两组无统计学意义(P>0.05)。1周和2周末,两组PSQI因子分及总分、HAMD、HAMA、CGI-SI分较治疗前均显著降低(P<0.01),研究组睡眠潜伏期、睡眠效率、白天功能紊乱因子分及PSQI总分显著低于对照组(P<0.05或P<0.01),PSQI平均减分率较对照组高(P<0.05)。对照组不良反应高于研究组(P<0.05)。结论右佐匹克隆治疗老年期失眠症安全、有效,改善主观睡眠质量优于阿普唑仑,不良反应少。 Objective To evaluate the efficacy and safety of eszopiclone in late-life insomnia.Methods 80 elder patients with insommia were randomized assigned to study group(n=40) treated with esczopiclone 3~6 mg/d or control group(n=40) treated with alprazolam 0.4~0.8 mg/d for 2weeks.PSQI,HAMD,HAMA and CGI were employed to evaluate the efficacy and outcomes.Security was evaluated with adverse events reports.Results The response rate of eszopiclone and alprazolam were 75.0% and 67.5%,respectively.At the end of 1,2 week,the score of total and subscales of PSQI,HAMD,HAMA,CGI-SI were significantly decreased in both groups(P0.01),and score of sleep latency,sleep efficiency,daytime dysfunction and total score of PSQI in eszopiclone group were significantly lower than that of alprazolam group(P0.05 or P0.01),and reducing rate of PSQI in eszopiclone was significantly higher than that of alprazolam(P0.05).Conclusion It is effective and safe of eszopiclone for late-life insomnia with advantages of improvement in quality of sleep.
出处 《中国现代药物应用》 2011年第4期12-13,共2页 Chinese Journal of Modern Drug Application
关键词 右佐匹克隆 老年期 失眠症 阿普唑仑 Eszopiclone Late-life Insomnia Alprazolam
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参考文献8

  • 1Ancoli-Israel S. Sleep and its disorders in aging populations. Sleep Med, 2009,10 Suppl 1 :S7-11.
  • 2Halas CJ. Eszopiclone. Am J Health Syst Pharm, 2006,63 ( 1 ) : 41-8.
  • 3中华医学会精神科分会.中国精神障碍分类与诊断标准第三版(CCMD-3).山东科学技术出版社,2001:87-89.
  • 4汪向东 五希林 马弘.心理卫生评定量表手册[M].中国心理卫生杂志社,2001.161.
  • 5McCrae CS, Ross A, Stripling A, et al. Eszopiclone for late-life insomnia. Clin Interv Aging, 2007,2 ( 3 ) : 313 -326.
  • 6Ye M, Garcia-Rill E. Potentiating effect of eszopiclone on GABA (A) receptor-mediated responses in pedunculopontine neurons. Sleep, 2009,32(7) :879-887.
  • 7Pollack M, Kinrys G, Krystal A, et al. Eszopiclone coadminis- tered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry, 2008,65 ( 5 ) : 551 - 562.
  • 8张卫华,王雪芹,付艺,杜波,李乐华,骆晓林,杨克勤,王洪源,张鸿燕.右旋佐匹克隆治疗失眠症的随机双盲对照试验[J].中国心理卫生杂志,2009,23(8):579-583. 被引量:35

二级参考文献17

  • 1刘琦,张鸿燕,阮晶,李华芳,李静,程焱,张微微.国产艾司佐匹克隆治疗失眠症的对照研究[J].中国新药杂志,2006,15(8):633-636. 被引量:20
  • 2国家食品药品监督管理局.药品注册管理办法[S/OL].北京:国家食品药品监督管理局.2007.7.10.[2009.2.2].http://www.sda.gov.cn/WS01/CL0053/24529.html.
  • 3国家食品药品监督管理局.药物临床试验质量管理规范[S/OL].北京:国家食品药品监督管理局.2003.8.6.[2009.2.2].http://www.sda.gov.cn/WS01/CL0053/24473.html.
  • 4Stephen M. Stahl. Stahl's Essential Psychopharmacology ( third edition) [ M] . New York: Cambridge University Press, 2008: 842.
  • 5Zammit GK, McNabb LJ, Caron J, et al. Efficacy and safety of eszopiclone across 6 - weeks of treatment for primary insomnia [J].Curr Med Res Opin, 2004, 20 (12) : 1979 -1991.
  • 6Rosenberg R, Caron J, Roth T, et al. An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults[J] . Sleep Me.d, 2005, 6 (1): 15-22.
  • 7Scharf M, Erman M, Rosenberg R, et al. A 2-week efficacy and safety study of eszopiclone in eldedy patients with primary insomnia [J] . Sleep, 2005, 28 (6): 720- 727.
  • 8Walsh JK, Krystal AD, Amato DA, et al. Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations [J]. Sleep, 2007, 30 (8): 959-68.
  • 9Roth T, Walsh JK, Krystal A, et al. An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia [J] . Sleep Med, 2005, 6 (6) : 487 - 95.
  • 10Erman MK, Zammit G, Rubens R, et al. A polysomnographic placebo-controlled evaluation of the efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary insomnia [ J] . J Clin Sleep Med, 2008, 4 (3) : 229 - 34.

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