黄芩提取物与有效成分抗亚洲甲型流感病毒作用的实验研究

Experimental Study on Anti-Influenza Virus Effect of Extracted Scutellaria And Effective Integridents

目的:比较两组黄芩提取物(河北黄芩水提组与黄芩成分配比物组)对流感病毒甲型鼠肺适应株(FM1)感染小鼠的死亡保护作用以及肺指数、肺组织病毒血凝滴度的影响。方法:以FM1感染小鼠为动物模型,感染1h后给药,以死亡率、肺指数、血凝滴度为评价指标,观察两组黄芩提取物在小鼠体内的抗流感病毒作用。结果:两组黄芩提取物均能降低流感病毒感染小鼠的死亡率。(P<0.05),延长小鼠的存活时间(P<0.05),降低肺指数(P<0.05),降低血凝滴度(P<0.05)。结论:两组黄芩提取物对FM1感染小鼠均具有良好的抗流感病毒感染作用,两组疗效相当,说明黄芩苷、汉黄芩素及黄芩素的合理配比可体现黄芩的药效质量。

Objective：Compare the effect of two groups extracted scutellaria（He Bei aqueous extract and scutellaria element ratio at random） on the death protection,lung index and hemagglutination titer of FM1 infected mice.Method： FM1 infected mice is animal model,the mice is treated after an hour,evaluation index including mortality,lung index and hemagglutination titer,observe the effect of different sources extracted scutellaria on anti-influenza virus effect.Result： Two groups extracted scutellaria both reduce mortality（P0.05）,prolong the survival time in mice（P0.05）,decrease lung index（P0.05）and reduce hemagglutination titer（P0.05）.Conclusion：Two groups extracted scutellaria both have anti-influenza virus effect,the reasonable ratio of baicalin,wogonin,baicalein embodying effect quality.