参附注射液、氨茶碱、纳洛酮和贝美格对老年患者全身麻醉苏醒质量的对比研究

The Comparison Study of Shenfu Injection,Aminophylline,Naloxone and Bemegride on the Quality of Recovery From General Anaesthesia in Old Patients

目的:探讨参附注射液、氨茶碱、纳洛酮和贝美格对老年患者全身麻醉苏醒质量。方法:全身麻醉下行择期腹部手术老年患者100例,按随机数字表法分为参附注射液组、氨茶碱组、纳洛酮组、贝格美组和对照组各20例。结果:参附注射液组、氨茶碱组、纳洛酮组、贝格美组的T1、T2和T2比对照组短(P<0.05);苏醒时间:纳洛酮组<贝美格组<氨茶碱组<参附注射液组<对照组。纳洛酮组和贝格美组的HR和MAP在拔管即刻和拔管后5min均高于对照组(P<0.05),参附注射液组与对照组无差异(P>0.05),氨茶碱组HR高于对照组(P<0.05),MAP无差异(P>0.05);对照组、氨茶碱组、纳洛酮组、贝美格组不良反应分别为10.0%(2/20)、30.0%(6/20)、35.0%(7/20)、25.0%(5/20),参附注射液组无不良反应。结论:参附注射液能明显加快全身麻醉苏醒,血液动力学平稳,心率和血压波动小,无明显不良反应,是一种安全、有效的老年患者全身麻醉促醒药物,值得临床推广应用。

Objective： To investigate the shenfu injection,aminophylline,naloxone and bemegride on the quality of recovery from general anaesthesia in old patients.Method： One hundred old patients undergoing elective abdominal operation with general anaesthesia were divided into shenfu injection group,aminophylline group,naloxone group,bemegride group and control group with 20 patients in each group according to the random digits table method.Results： The T1,T2 and T2 of shenfu injection group,aminophylline group,naloxone group,and bemegride group were shorter than control group（P0.05）;Awakening time： naloxone groupbemegride groupaminophylline groupshenfu injection groupcontrol group.The HR and MAP in naloxone group and bemegride group were higher than control group at the time of extubation immediately and 5 min after extubation（P0.05）,and there is no difference in shenfu injection group and control group（P0.05）;HR in aminophylline group was higher than control group（P0.05） while there was no difference on MAP（P0.05）.The adverse reactions in control group,aminophylline group,naloxone group,bemegride group were 10.0%（2/20）,30.0%（6/20）,35.0%（7/20）,25.0%（5/20） respectively,and there was no side effect in shenfu injection group.Conclusion： Shenfu injection can quicken awaking from general anaesthesia obviously,with stable haemodynamics,minimal heart rate and blood pressure and without remarkable adverse reaction.It has optimal quality of recovery from general anaesthesia,which is a safe and effective agrypnotic in old patients undergoing general anaesthesia and worth to spread and apply in clinic.