摘要
乙酰胆碱酯酶在神经突触间隙中通过催化水解神经递质乙酰胆碱来维持神经冲动的正常传递,广泛存在于各种动物组织中,如脑、红血球、鱼肉组织和动物血清中。总结了最近国内外关于乙酰胆碱酯酶的研究进展,包括乙酰胆碱酯酶的提取、纯化和固定化研究,且综述了有关乙酰胆碱酯酶传感器的应用进展,以及在治疗疾病如阿尔茨海默病方面的应用,这将为以乙酰胆碱酯酶为目标的研究提供信息框架。
Acetylcholinesterase(AChE) maintained the normal nerve impulse transmission by the neurotransmitter acetylcholine hydrolysis in the synaptic gap and widely distributed in various animal tissues like brain,red blood cells,fish tissue and animal serumetc.The recent research pregress on AChE was reviewed in this study,including the extraction,purification and immobilization method of the AChE,the application of sensor made of AChE,and also the treatment of the disease such as Alzheimer's disease(AD) with the AChE.This study would provide information frame of the enzyme for further study and application of AChE.
出处
《安徽农业科学》
CAS
北大核心
2011年第7期3811-3814,共4页
Journal of Anhui Agricultural Sciences
基金
国家自然科学基金项目(30870340)
重庆市自然科学基金重点项目(CSTC2008BA5030)
关键词
乙酰胆碱酯酶
分离纯化
酶的固定
传感器
阿尔茨海默病
Acetylcholinesterase(AChE)
Separation and purification
Enzyme immobilization
Sensor
Alzheimer's disease