乙酰胆碱酯酶的分离纯化及生物学研究进展

Research Progress of Seperation,Purification and Biology of Acetylcholinesterase

乙酰胆碱酯酶在神经突触间隙中通过催化水解神经递质乙酰胆碱来维持神经冲动的正常传递,广泛存在于各种动物组织中,如脑、红血球、鱼肉组织和动物血清中。总结了最近国内外关于乙酰胆碱酯酶的研究进展,包括乙酰胆碱酯酶的提取、纯化和固定化研究,且综述了有关乙酰胆碱酯酶传感器的应用进展,以及在治疗疾病如阿尔茨海默病方面的应用,这将为以乙酰胆碱酯酶为目标的研究提供信息框架。

Acetylcholinesterase（AChE） maintained the normal nerve impulse transmission by the neurotransmitter acetylcholine hydrolysis in the synaptic gap and widely distributed in various animal tissues like brain,red blood cells,fish tissue and animal serumetc.The recent research pregress on AChE was reviewed in this study,including the extraction,purification and immobilization method of the AChE,the application of sensor made of AChE,and also the treatment of the disease such as Alzheimer＇s disease（AD） with the AChE.This study would provide information frame of the enzyme for further study and application of AChE.