人乳头状瘤病毒感染与肺癌关系的研究进展

Research progress of relationship between human papillomavirus infection and lung cancer

近年越来越多的研究发现肺癌组织中有人乳头状瘤病毒(human papillomavirus,HPV)DNA和癌蛋白的检出,其检出率具有地域差异性,但不同地方HPV检出亚型具有高度的一致性,主要是高危型HPV-16和HPV-18。HPV可能主要通过血液循环从宫颈癌病灶等原发部位转移到肺,从而可能诱发肺癌的发生。HPV诱发肺癌的机制可能与影响p53的失活及端粒酶的激活等有关。

In recent years,a number of studies showed that HPV-DNA and oncoproteins were detected in lung cancer tissues.The detection rate was from 0 to 80% with the differences of regions,but there was no significant difference between HPV subtypes in lung cancer,and high-risk types HPV-16 and-18 were most frequently at present.HPV infected lung from primary cervical cancer may mainly through blood circulation.The mechanism of HPV-induced lung cancer may be related to inactivation of p53 and activation of telomerase.