摘要
近年越来越多的研究发现肺癌组织中有人乳头状瘤病毒(human papillomavirus,HPV)DNA和癌蛋白的检出,其检出率具有地域差异性,但不同地方HPV检出亚型具有高度的一致性,主要是高危型HPV-16和HPV-18。HPV可能主要通过血液循环从宫颈癌病灶等原发部位转移到肺,从而可能诱发肺癌的发生。HPV诱发肺癌的机制可能与影响p53的失活及端粒酶的激活等有关。
In recent years,a number of studies showed that HPV-DNA and oncoproteins were detected in lung cancer tissues.The detection rate was from 0 to 80% with the differences of regions,but there was no significant difference between HPV subtypes in lung cancer,and high-risk types HPV-16 and-18 were most frequently at present.HPV infected lung from primary cervical cancer may mainly through blood circulation.The mechanism of HPV-induced lung cancer may be related to inactivation of p53 and activation of telomerase.
出处
《生命科学》
CSCD
北大核心
2011年第3期261-266,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(30872944
81073103)
广东省第二批科学事业费科技计划项目(2009B030801330)
广东省中医药局建设中医药强省科研项目(2008166)
东莞市高等院校科研机构和医疗卫生单位科技计划项目(2008108101047)