纳洛酮对心搏骤停患者氧化应激反应及心肺复苏的影响研究

The study to effect of naloxone in oxidative stress and cardiopulmonary resuscitation in emergency of cardiac arrest

目的探讨纳洛酮对心搏骤停患者心肺脑复苏过程中氧化应激反应及心肺复苏效果的影响。方法选择心肺复苏抢救的心搏骤停急救患者68例,随机将患者分为观察组和对照组,每组各34例。患者均采取心肺复苏救治,使用血管活性药物及细胞活性药物,观察组患者在复苏过程中加用纳洛酮静脉应用,观察两组患者心肺复苏时间、心肺复苏成功率及24 h存活率,患者心肺复苏后及复苏24 h后血清超氧化物歧化酶(super oxide dismutase,SOD)及丙二醛(malondialdehyde,MDA)水平。结果同对照组比较,观察组患者心肺复苏时间短于对照组,心肺复苏成功率高于对照组,治疗24 h后,观察组患者存活率高于对照组,心肺复苏后及心肺复苏24 h后,治疗组患者血清SOD水平高于对照组,MDA水平低于对照组。结论纳洛酮能够减轻心搏骤停患者体内氧化应激损伤,改善心肺复苏效果及预后。

Objective To investigate the effect of naloxone in oxidative stress and cardiopulmonary resuscitation in emergency of cardiac arrest.Methods 68 patients who taken cardiopulmonary resuscitation（CPR） for emergency cardiac arrest in our hospital were selected and randomly divided into control group and observation group,34 patients each group.All patients received first aid with CPR and treatment with vasoactive agent and cytoactive medicine.Patients of observation group were taken additional medication in vein with naloxone,effect of cardiopulmonary resuscitation were observed,survival rates in 24 h were compared,while malondialdehyde（MDA）and super oxide dismutase（SOD） in serum were contrasted.Results Compared with control group,the time of cardiopulmonary resuscitation was shorter,and the success rate was significantly increased in observation group,and survival rate in 24 h were increased in observation group.The level of MDA was higher and SOD was higher at once and 24 h after CRP in observation group.Conclusion Naloxone could decrease oxidative stress damage on cardiac arrest,and improve effect of CRP.