缺血性脑卒中患者高同型半胱氨酸血症的危险因素的研究

Study on the Risk Factors of Hyperhomocysteinemia in Ischemic Stroke Patients

目的在缺血性脑卒中患者中探讨高同型半胱氨酸血症(HHe)的危险因素。方法回顾性分析,将缺血性脑卒中患者690例,分为伴HHe组329例,不伴HHe组361例,调查年龄、性别、症状、体征、吸烟饮酒史,是否伴高血压病、糖尿病病史,血浆同型半胱氨酸(Hcy)、叶酸、维生素B12、胆固醇(TC)、甘油三酯(TG)浓度。用logistic回归进行统计学分析。结果性别、年龄、吸烟指数、叶酸、维生素B12浓度进入logistic回归模型,[OR=2.279(95%CI1.498～3.524),OR=1.039(95%CI1.022～1.056),OR=1.001(95%CI1.000～1.001),OR=0.830(95%CI0.786～0.876),OR=0.998(95%CI0.997～0.999)]。结论男性、老龄、吸烟及叶酸和维生素B12浓度的降低为缺血性卒中患者HHe的独立危险因素。

Objective To study the risk factors of hyperhomocysteinemia（HHe） in ischemic stroke patients.Methods This is a retrospective study.Ischemic stroke patients（n=690） were classified based on homocysteine concentrations,and therefore were divided into patients with HHe group （n=329） and patients without HHe group （n=361）.Age,gender,symptoms,signs,history of cigarettes smoking,drinking,hypertension and diabetes,plasma homocysteine,folate,vitamin B12,total cholesterol and triglyeride concentrations were recorded and compared between the two groups.Logistic regression was used for statistical analysis.Results Parameters such as gender,Age,smoking index,folate and vitamin B12 concentrations were tested by the logistic regression model.[OR=2.279 （95%CI1.498～3.524）,OR=1.039（95%CI1.022～1.056）,OR=1.001（95%1.000～1.001）,OR=0.830（95%CI0.786～0.876）,OR=0.998（95%CI0.997～0.999）].Conclusion Male,old age,smoking,lowered folate and vitamin B12 concentrations are independent risk factors for HHe in ischemic stroke patients.