38例药物性肝炎的临床分析

The clinical analysis of 38 cases with drug-induced hepatitis

目的:分析药物性肝炎的临床特点。方法:回顾性分析38例药物性肝炎患者的临床资料,对其预后、药物种类、临床分型及发病时间进行总结分析。结果:导致药物性肝炎的药物种类繁多,以抗结核药为主,其次为中药;肝细胞损害性肝炎者有15例,胆汁淤滞型有9例,混合型有14例;15例患者发病时间为14～21 d,12例患者在22～28 d之间发病,11例患者的发病时间为28 d以上;32例患者预后良好,6例发生重型肝炎,除1例死亡外,均痊愈出院。结论:抗结核药和中药是引起药物性肝炎的主要药物,应引起足够的重视。

Objective To analyze the clinical features of drug-induced hepatitis.Methods A retrospective analysis was used to analyze the clinical data of 38 cases with drug-induced hepatitis,and its prognosis,drug type,clinical type and duration of the disease.Results The drugs which could cause drug-induced hepatitis were various,anti-TB drugs,was the most important one,followed by traditional Chinese medicine;15 cases were of liver cell damaged hepatitis,9 cases were of cholestatic type,14 cases were of mixed type;15 patients＇onset time was among 14～21 days,12 patients between 22～28 days,11 patients＇onset time was over 28 days;32 patients had good prognosis,6 patients had severe hepatitis,1 patient died.Conclusion The anti-TB drugs and Chinese medicine are the main cause of drug-induced hepatitis drugs,which should be given sufficient attention.