肺结节病患者不同时期肺功能变化研究

Study of pulmonary function changes in different phases of the patients with pulmonary sarcoidosis

目的通过测定肺结节病患者不同时期的肺通气功能,并就其之间的相关性进行分析。方法对肺结节病患者不同时期,行肺通气功能和弥散功能检测,肺结节病患者静息状态肺通气功能基本正常(P>0.05),单口呼吸法肺弥散功能(DL-CO%)减低(P<0.05),并有小气道功能障碍,尤以FEF50%减低明显(P<0.05)。结果显示此类患者表现为限制性通气功能障碍并伴有弥散功能下降和小气道功能受限。结论肺弥散功能以及小气道功能的检查,可作为肺结节病病情活动性及指导治疗判断预后的一项重要参考指标。

Objective To analyze the pulmonary ventilation function changes in different phases of the patients with pulmonary sarcoidosis. Methods Pulmonary ventilation and diffusion function were measured in different phases of the patients with pulmonary sareoidosis. Results Pulmonary ventilation function was normal in static phase of the patients, while pulmonary ventilation function and small airway function were disordered. The diffusion capacity of carbon monoxide （ DLCO% ） and peak expiratory flow 50% （ FEF50% ） were significant decreased. Patients showed pulmonary ventilation function disturbance, pulmonary diffusion function degression and small airway function disturbance. Conclusion Pulmonary diffusion function examination and small airway function examination were important index for patients of pulmonary sarcoidosis in diagnosis and trealment.