血清β2-MG和Scc联合检测对肺鳞癌临床意义

Clinical Significance of β2-MG and Scc in the diagnosis of sqamous cell lung cancer

目的研究血清肿瘤标记物Scc、β2-MG对肺鳞癌的诊断价值和临床意义。方法将研究对象分组,实验组为肺鳞癌组,对照组为良性肺病组。分别采用免疫浊度法、电化学发光法检测血清β2-MG、Scc,测定值用t检验,率比较用卡方检验。二者相关性分析用Spearman等级相关分析。结果敏感性:β2-MG高于Scc(P<0.05),联合检测高于单一检测(P<0.05)。特异性:Scc高于β2-MG和联合检测(P<0.05),β2-MG与联合检测无明显差异(P>0.05)。准确性:β2-MG高于Scc(P<0.05),联合检测高于单一检测(P<0.05)。Scc和β2-MG无相关性。β2-MG血清浓度达到正常范围上限六倍时,累计频率为92.20%。结论联合检测可提高肺鳞癌诊断的敏感性和准确性。β2-MG肺鳞癌诊断敏感性和准确性高于Scc,Scc和β2-MG无相关性。

Objective To investigate the value and the clinical significance of squamous cell carcinoma antigen（Scc）and β2-mi- croballoons protein （β2-MG） in the diagnosis of sqamous cell lung cancer. Methods The patients were divided into two groups： the sqamous cell lung cancer group and the benign lung disease group. The electric chemisty irradiance and inmunity nephelometer was re- spectively used to examine blood serum β2-MG and Scc. Levene＇ Test was used to detected the homogeneity of variance test Satterthwaite test or the same variance used t-test was used to detected the difference variance. The sensitive rate, the specificity rate and the accuracy rate comparison were examined by Chi-square test. Spearman correlation analysis was used to analysis the correlation of β2-MG and Sec. Results The sensitive rate of β2-MG was higher than that of Sec （ P 〈 0.05 ）. The combined examination was higher than β2-MG（ P 〈 0. 05）. The specificity rate：β2-MG was the same as combined examination （P 〉 0. 05）. The union examination and β2-MG was lower than Scc（ P 〈 0.05 ）. The accuracy rate：β2-MG was higher than Scc （P 〈 0.05 ）. conbined examination was higher than β2-MG and Scc （ P 〈 0.05 ）. The spearman correlation analysis ： β2-MG and Scc had no correlation, they could be used to united examination. The serum tumor markers of Scc was six-fold than normal level, the cumulative percent was 92.2 percent. Conclusions Combined examination of β2-MG and Scc may improve sensitive and accuracy in the diagnosis of sqamous cell lung cancer. β2-MG and Scc have no correlations.