摘要
目的:评价藏雪玛牌虫草胶囊的安全性。方法:依据食品安全性毒理学评价程序和方法进行急性毒理、骨髓细胞微核、精子畸形、Ames和30 d喂养实验。结果:小鼠经口最大给药量>24 g·kg-1,属实际无毒级;骨髓细胞微核、精子畸形和Ames实验结果均为阴性;30 d喂养实验中各项指标均未见异常。结论:藏雪玛牌藏虫草胶囊是较安全的。
OBJECTIVE:To evaluate the safety of Tibetan cordyceps capsules.METHODS:Acute toxicity test,bone marrow cell micronucleus test,mice sperm abnormality test,Ames test and 30 days feeding test were conducted according to the procedures and method of food toxicological evaluation.RESULTS:The oral maximum dose(MTD) for mice was more than 24 g·kg-1,being involved in actually nontoxic grade;Results of marrow cell micronucles test,mice sperm abnormality test,and Ames test were negative;all indexes in 30 days feeding test were not abnormal.CONCLUSION:Tibetan cordyceps capsules is safe in this study.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第15期1367-1370,共4页
China Pharmacy
关键词
藏虫草胶囊
毒理学
安全性
Tibetan cordyceps capsules
Toxicology
Safety