缺失型血管紧张素转换酶基因与心肌梗塞的关系

Relation Between Deletion Polymorphism of the Angiotensin - converting Enzgme Gene and Myocardial Infarction

目的：探讨缺失型（ＤＤ）血管紧张素转换酶（ＡＣＥ）基因与冠心病的相关性。方法：收集５５例心肌梗塞患者及４７例附照组，用 ＰＣＲ技术检测 ＡＣＥ基因缺失／插入多态性。结果：心肌梗塞组 ＡＣＥ ＤＤ、Ｄ基因频率分别为 ０．８０、０．８７较对照组 ０．８３，０．８３无显著统计学差异（Ｐ＞０．０５）。结论：缺失型ＡＣＥ基因可能与冠心病发病无关联。

objective:To explore the relation between deletion polymorphism of the angiotensin-converting enzyme(ACE)gene and myocardial infc tion. Methods: The deletion(D) / insertion(I) polymorphism of the AcE gene was determined by polymerase chain reaction in 55 sruvivors of myocardial infarction and in 47 controls. Results: There were no differences of DD,D frequency of ACE gene between patient group and cntrol group (P >0.05), Conclusion: The association of deletion polymorphism of ACE gene with myocardial infarction was not found.