联合应用纳络酮、尿激酶及低分子肝素治疗急性脑梗塞的临床研究

The Treatment of Patients Sufter Fram Acute Cerebral Infarction Using Naloxone, Urokinase and Low Molecular Heparin

目的：本文联合应用纳诺酮、尿激酶及低分子肝素治疗３５例急性脑梗塞（ＡＣＩ）患者（治疗组），观察其治疗前后的β－内啡肽（β－ＥＰ）改变及临床疗效，方法：并与３０例常规药物治疗组（对照组）比较。结果：结果显示，两组患者的血浆β－ＥＰ浓度均明显高于正常组，治疗组治疗后，其β－ＥＰ浓度显著下降，临床疗效明显高于对照组。提示纳络酮能明显降低（ＡＣＩ）患者的血浆β－ＥＰ浓度。结论三药联合应用的临床疗效明显优于对照组。

objective:The treatment of 35 patients suffering from acute cerebrae infarction (ACI) using Naloxone, urokinase(Uk)and low molecular heparin(IMH)was observed (The treatment group), Methods: The treatment group was compared with 30 cases receiving only routine treatment (control group), Aftel treatment with medicine, the effect of treatment was observed, and β-endorphine(β-EP)was detected. Results:The resuks. showed that the levels of β-EP were significantly higher in treatment group and control group than those in normal subjects,The levels of β-EP were markedly lower in treatment group after treatment using Naloxone, Uk and IMH, and the effect of treatment was markedly higher than that of control group. Conclusion:We conclude that the levels of β-EP in treatment group can be decreased by using Naloxone, The effect of treatment using Mal oxone, Uk and IMH was obviously higher than that of using routine treatment.