煤工尘肺发生早期的自由基代谢变化

Metabolic Changes of Free Radical in Early Stage of Coal Workers' Pneumoconiosis

为探讨煤工尘肺发生早期的自由基代谢变化，系统测定５４ 例Ⅰ期煤工尘肺患者，５９ 例 Ｘ 线表现尚不足以诊断为Ⅰ期尘肺的０ ＋ 人群及４０ 例健康对照者血液中的过氧化脂质（ Ｌ Ｐ Ｏ） 、唾液酸（ Ｓ Ａ） 、谷胱甘肽（ Ｇ Ｓ Ｈ） 、维生素 Ａ（ Ｖ Ａ） 、维生素 Ｅ（ Ｖ Ｅ） 含量及超氧化物歧化酶（ Ｓ Ｏ Ｄ） 、谷胱甘肽过氧化物酶（ Ｇ Ｓ Ｈ Ｐｘ） 和过氧化氢酶（ Ｃ Ａ Ｔ） 活力。结果显示，０ ＋ 组人群及Ⅰ期煤工尘肺患者体内 Ｌ Ｐ Ｏ 及 Ｓ Ａ 水平均明显高于对照组，而 Ｇ Ｓ Ｈ Ｐｘ ， Ｃ Ａ Ｔ 活力及 Ｖ Ａ、 Ｖ Ｅ 含量则较对照组明显降低， Ｓ Ｏ Ｄ则呈代偿性增加。表明自由基代谢紊乱及氧化／ 抗氧化状态失衡的变化早于煤工尘肺诊断的 Ｘ 线影像学改变。

In order to explore the status of free radical metabolism in early stage of coal workers' pneumoconiosis (CWP),the blood levels of lipoperoxide (LPO),sialic acid (SA),glutathione (GSH),Vitamin A (VA),Vitamin E (VE),and the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and catalase (CAT) were systematically measured in 54 patients with CWP of phase Ⅰ,59 O + subjects(not sufficiently diagnosed as CWP of Ⅰ Phase in x ray) and 40 healthy subjects.The results showeed that the levels of LPO and SA in the patient with CWP of phase Ⅰ and O + subjects were significantly higher than those of the healthy subjects,whereas the average levels of GSH Px,CAT,VA and VEwere significantly lower than those of the control group.The levels of SOD and GSH were also compensatedly increased.It is suggested that the changes of metabolic disturbance of free radical and the imblance of lipoperoxidation/antioxidation were earlier than those in the x ray diagnosis of CWP.