莫西沙星和阿奇霉素治疗血白细胞不高的社区获得性肺炎疗效观察

Curative Effects of Moxifloxacin and Azitromycin in Treating Leukopenia or Normal Leucocyte Community Acquired Pneumonia

目的观察莫西沙星治疗血白细胞不高的社区获得性肺炎的疗效。方法采用随机对照方案,用阿奇霉素为对照药。实验组60例,予莫西沙星氯化钠注射液0.4静脉点滴,对照组50例,予阿奇霉素0.5加0.9%氯化钠注射液500mL中静脉滴注,疗程7～10d。结果莫西沙星组总有效率80%,阿奇霉素组总有效率62%,统计学上有显著差异(P<0.05)。不良反应莫西沙星组为5%,阿奇霉素组为20%。结论莫西沙星经验治疗血白细胞不高的社区获得性肺炎较阿奇霉素有更好的疗效,更少的不良反应,值得临床推广应用。

Objective Observation of curative effect of Moxifloxacin in treating leukopenia or normal leucocyte community acquired pneumonia.Method Randomized control method was adopted using Azitromycin for control.60 cases from the research group were injected with Moxifloxacin and sodium chloride injection 0.4 through intravenous drip infusion.50 cases from the control group were injected with Azitromycin 0.5 added to 500mL of 0.9% sodium chloride injection through intravenous drop infusion.The course of treatment lasted for 7 to 10 days.Result Total effective rate of the Moxifloxacin group was 80% and Azitromycin group 62%.Significant statistical difference was found（P0.05）.Untoward reaction rate for Moxifloxacin group was 5% and Azitromycin group 20%.Conclusion Moxifloxacin proved to be higher curative effect and less untoward reaction,compared with Azitromycin,in treating leukopenia or normal leucocyte community acquired pneumonia,which made it more suitable for clinical application.