摘要
目的:观察抑癌基因 p16,p21 及 p53 在鼻咽癌( N P C)的表达,探讨其与 N P C的发生发展及预后的关系。方法:用免疫组化 S P法检测了 116 例 N P C 组织和 15 例无瘤鼻咽( N P)组织的 p16,p21 及 p53 基因的表达情况。结果:① N P C 组中 p16,p21,p53 阳性率分别为64.7% ,45.7% 和90.5% ;与 N P组比较,差异均有统计学意义( P< 0.05)。②p16 在 N P C非角化型阳性率为70.6% ,未分化型阳性率为44.8% ,两者有显著性差异( P< 0.05)。③p21 与 p16,p53 阳性表达之间有相关性。结论:p16,p21 的低表达与 N P C 的发生密切相关,p16 异常表达与细胞分化程度有一定关系,p16 与 p21 在 N P C的发生发展中存在协同作用;p21 可能不是通过野生型 p53
Objective:To evaluate the roles of p16,p21 and p53 protein expression in nasopharyngeal carcinoma (NPC).Method:The SP immunohistochemical method was used to detect the expression of p16,p21 and p53 protein in 116 cases of NPC and 15 cases of non tumour nasopharyngeal tissue.Result:①The positive expression rates of p16,p21 and p53 protein were 64.7 %, 45.7 % and 90.5 % in NPC respectively.There were significant differences between NPC and non tumour group (P< 0.05 ).②The expressive rate of p16 protein was 70.6 % in non keratinizing type, 44.8 % in undifferentiated type (P< 0.05 ).③The positive expression of p21 was correlated with the expression of p16 and p53.Conclusion:Low expressions of p16 and p21 protein may play an important role in carcinogensis of NPC,and that of p16 has some relation to cell differentiation of NPC.p16 protein may cooperate with p21 protein in development of NPC.p21 protein is probably not produced by stimulating wild type p53 protein.
出处
《临床耳鼻咽喉科杂志》
CSCD
1999年第9期406-408,共3页
Journal of Clinical Otorhinolaryngology