围绝经期综合征中医证素特点研究

Research on Features of TCM Syndrome Elements in Perimenopausal Syndrome

目的：探讨围绝经期综合征中医证素特点。方法：选择64例围绝经期综合征患者作为观察对象,采用证素辨证及积分方法进行临床观察。结果：①围绝经期综合征患者的病位主要在肝、肾、胞宫、脾、胃。②围绝经期综合征虚证证素积分从高到低依次为阴虚、气虚、血虚、阳虚,阴虚积分显著高于气虚、血虚、阳虚积分（P〈0.05~P〈0.01）。③实证证素积分从高到低依次为气滞、湿、热、血瘀、寒、痰,气滞积分显著高于热、血瘀、寒、痰积分（P〈0.05~P〈0.01）。结论：围绝经期综合征的发病源于肾虚,发于肝郁,病性属虚实夹杂,肾阴虚、肝气滞为其病理变化的关键环节。

Objective：To explore the features of TCM syndrome elements in perimenopausal syndrome（PMS）.Methods：64 PMS patients were observed by syndrome elements differentiation and integral methods in clinic.Results：①The main locations of disease in PMS were liver,kidney,uterus,spleen and stomach.②In asthenia syndromes in PMS,the integrals of syndrome elements were gradually reduced from Yin deficiency to Qi deficiency to blood deficiency to Yang deficiency.The integral of syndrome element of Yin deficiency was significantlyhigher than that of Qi deficiency,blood deficiency and Yang deficiency respectively（P0.05~P0.01）.③In sthenia syndromes in PMS,the integrals of syndrome elements were gradually reduced from Qi stagnation to dampness to heat to blood stasis to cold to phlegm.The integral of syndrome element of Qi stagnation was significantlyhigher than that ofheat,blood stasis,cold and phlegm respectively（P0.05~P0.01）.Conclusion：In PMS,kidney deficiency and liver depression were the basic pathological mechanisms.The nature of disease in PMS was the mixture of asthenia and sthenia.kidney-yin deficiency and liver-qi stagnation were the key links of pathological changes in PMS.