卡铂、氟尿嘧啶化疗结合放射治疗非小细胞肺癌疗效分析

The combined therapy of carboplatin, fluorouracil and radiotherapy for moderate and advanced non small cell lung cancer

目的 观察卡铂（ Ｃ） 、氟尿嘧啶（ Ｆ） 化疗加放射治疗（ 放疗） 对中晚期非小细胞肺癌（ Ｎ Ｓ Ｃ Ｌ Ｃ） 的疗效。方法 选择中晚期 Ｎ Ｓ Ｃ Ｌ Ｃ８０ 例随机入 Ｃ Ｆ＋ 放疗和单纯放疗组，两组病例均给予常规放疗， Ｃ Ｆ＋ 放疗组放疗第１ 、４ 周给予化疗，卡铂１００ ｍｇ、氟尿嘧啶５００ ｍｇ 静脉滴注，每周连用５ 天。结果 近期疗效完全缓解率 Ｃ Ｆ＋ 放疗组为４８ ％ ，单纯放疗组为２５ ％ ，１ 、３ 、５ 年生存率 Ｃ Ｆ＋ 放疗组分别为６３ ％ 、３８ ％ 和１８ ％ ，较单纯放疗组的４０ ％ 、１５ ％ 和８ ％ 有明显提高， Ｃ Ｆ＋ 放疗组毒副反应主要是Ⅰ、Ⅱ度骨髓抑制和消化道反应。结论 卡铂、氟尿嘧啶化疗结合放疗，能提高 Ｎ Ｓ Ｃ Ｌ Ｃ 的疗效及生存率。

Objective To observe the effect of combined chemotherapy (carboplatin and fluorouracil) with radiotherapy for moderate and advanced non small cell lung cancer Methods Eighty patients with moderate and advanced non small cell lung cancer were randomized into 2 groups,radiotherapy group(R) and carboplatin,fluorouracil plus radiotherapy group(CF+R) All patients in two groups received conventional radiotherapy Patients in CF+R group received combined chemotherapy with carboplatin(100 mg, d 1 5)、5 fluorouracil(500 mg d 1 5) in the first and fourth weeks during radiotherapy Results The complete response rate was 48% in CF+R group, 25% in R group The 1 year, 3 year, 5 year survival rates were 63%, 38%,18% in CF+R group,and 40%, 15%, 8% in R group The major toxic reactions in CF+R group were grade Ⅰ～Ⅱ myelo suppression and digestive tract reaction Conclusions Combined chemotherapy(carboplatin and fluorouracil)with radiotherapy is preferable for non small cell lung cancer