血吸虫病肝纤维化的发病机制研究进展

Research advances in pathogenesis of schistosomiasis hepatic fibrosis

血吸虫虫卵引起的肝脏肉芽肿和纤维化病变是导致血吸虫病患者死亡的主要原因。血吸虫病的病理基础是宿主对成熟虫卵释放的可溶性虫卵抗原产生的免疫应答反应。该文对血吸虫病肝纤维化的细胞和分子机制进行了综述。

The primary cause of death in schistosomiasis is the formation of liver egg granulomas and secondary hepatic fibrosis. The pathological basis of schistosomiasis is the host＇s immune response to the soluble egg antigens secreted by the mature eggs. This article reviewed the research advances in cellular and molecular mechanisms of schistosomiasis hepatic fibrosis.