哮喘患儿外周血CD56、CD25检测的临床意义

Clinical significance of the detection of peripheral blood CD 56,CD 25 levels in asthmatic children

目的：探讨哮喘息儿外周血分化群（CD）56、CD25水平检测的临床意义。方法：应用流式细胞仪（FCM）检测哮喘患儿外周血单个核细胞中CD56+、CD25+细胞数。结果：缓解期组CD56十细胞数百分比[（12.0±3．1）％］及CD25+细胞数百分比[（4．1±2．2）％]与正常对照组比较均无显著性差异（P＞0．05）；哮喘发作组CD56+细胞数百分比[（9、4±2．2）％]低于正常对照组[（11．9±3．2）％]及缓解期组（P＜0．01）；哮喘发作组CD25+细胞数百分比[（7.2±2．1）％]高于正常对照组[（4．1±1．8）％]及缓解期组（P＜0．01）。结论：CD56+、CD25+细胞数与小儿哮喘的发病过程有一定关系。

Objective:To evaluate the clinical significance of peripheral blood CD 56, CD 25 levels in asthmaticchildren. Methods:The percentage of peripheral blood mononuclear cells CD 56+, CD 25+ cells of asthmatic childrenwere assayed by means of a flow cytometric assay. Results:The percentage of CD 56+ cells [ (12.0±3.1) %] and CD25+ cells [(4.1±2. 2) %] in remission stage had no significant difference compared with the control (P>0. 05);thepercentage of CD 56+ cells in acute attack [(9. 4±2.2) %] was significantly lower than that of the control [(11. 9±3. 2) %] and that of the remission (P<0.01), while the percentage of CD 25+ cells [ (7.2±2. 1) %] in acute attackwas significantly higher than that of the control [(4.1±1. 8) %] and that of the remission (P<0.01).Conclusiou:The percentage of CD 56+and CD 25+ cells are at least partly related to the development of childhood asthma.