215例慢性前列腺炎致病菌及药物敏感性分析

Analysis of causative pathogen and its drug sensitivity of 215 cases of chronic prostatitis

目的：了解慢性前列腺炎的致病菌及其对药物的敏感性。方法：对性病门诊215树前列腺液标本用常规血琼脂平板分离和纯化致病菌，采用美国Sceptor细菌鉴定仪及配套生化鉴定板和药敏试验板进行生化试验和药物敏感性试验。结果：分离出病原菌135株，分离阳性率为62．8％。以表皮葡萄球菌（45株）、金黄色葡萄球菌（39株）、大肠杆菌（16株）为最多见。药物敏感性试验结果显示，表皮葡萄球菌对万古霉素、克林霉素和利福平较敏感，金黄色葡萄球菌对头孢唑林、阿米卡星、万古霉素敏感性较高，而大肠杆菌对氨基糖苷类、头孢菌素类较敏感。同时检测出耐甲氧西林表皮葡萄球菌（MRSE）和耐甲氧西林金黄色葡萄球菌（MRSA）共14株。结论：性病门诊慢性前列腺炎的致病菌以葡萄球菌和大肠杆菌为最常见，其中MRSE和MRSA占分离病原菌的10．4％；细菌培养与药物敏感性试验对诊治慢性前列腺炎有较高的临床参考价值。

Objective:To investigate the causative pathogen for chronic prostatitis and its drug sensitivity spec-trum. Methods: 215 specimens of prostatic secretion were obtained from 215 patients with chronic prostatitis in theSexually Transmitted Diseases (STD) Clinic.Blood agar plate was routinely used for isolation and purification ofcausative microorganism. The Sceptor bacterial identification instrument and its accessory made in United States wereused for biochemical analysis and drug sensitivity test. Results: 135 cases had positive cultures from prostate secre-tion. The positive rate was 62.8%. The three most frequent bacteria isolated from the specimens were Staphylococcusrpidermis (45 strains ) Staphylococcus aureus (39 strains ) and E. scherichia coli (16 strains ). S. epidermidis was moresensitive to vancomycin, clindamycin and rifampicin. S.aureus was more sensitive to cefazolin, amikacin and van-comycin.However, E.coli was more sensitive to aminoglycoside, cephalosporins. Furthermore, 14 strains of MRSEand MRSA were detected. Conclusions:Staphylococci and E.coli were the most frequent isolates in patients withchronic prostatitis in STD Clinic- More than 10% of the total strains being investigated. were MRSE and MRSA.Therefore, bacterial culture and drug sensitivity tests are important in clinical diagnosis and treatment of chronic pros-titits.