葛根素治疗急性脑梗死的疗效及机制探讨──附22例资料分析

Observation on clinical efficacy of puerarin in the treatment of acute cerehral inrarction

目的：观察葛根素注射液对急性脑梗死（ACI）的治疗作用。方法：44例ACI患者随机分为两组，葛根素治疗组（A组）22例应用葛根素500mg加5％葡萄糖溶液静脉满注，每日1次，共14天；低分子右旋糖酐组（B组）22例应用低分子右旋糖酐500mL，方法与疗程同A组。分别于治疗前及治疗2疗程后作神经功能缺损评分；同时观察血流动力学、心电图、梗死灶体积大小等指标的变化以评定临床疗效。结果：治疗后A组有效率82％，明显高于B组45％，（P＜0．01）。且A组治疗后血浆黏度、全血高切黏度、全血低切黏度及纤维蛋白原定量均显著下降；且CT扫描病灶比治疗前缩小校B组明显。结论：葛根素能明显改善ACI患者的血流动力学指标，且安全、疗效可靠，可作为ACI治疗的一种新选择。

Objective:To observe the clinical efficacy of puerarin in the treatment of acute cerebral infarction(ACI),Methods: 44 patients of ACI were randomly divided into two group.Patient in A group (n = 22 ) were treatedwith puerarin (500 mg/d ), while subject in B group (n= 22) were treated with dextram (500 mL,/d) for a course of14 days. The neurological deficit scores, hemorrheological indexes, electrocardiogram and size of infarction foci of allpatients were compared before and after treatment to evaluate the clinical efficacy.Results: The overall effective rateof A group was remarkable higher than that of B group (82% vs 45%, P<0. 01).Plasma viscosity, whole blood vis-cosity, plasma fibrinogen content and size of infarction foci were significantly reduced in A group. Conclusion:Puerarincan significant1y improve the hemorrheological indexes of ACl patients. it is a safe and effective drug and can be usedas an alternative method in the treatment of ACI.