地鳖虫对小鼠免疫功能的调节作用

Regulatory effects of Eupolyphaga sinensis on immunological function in mice

研究中华真地鳖Eupolyphaga sinensis Walker免疫调节作用。经口给予小鼠1.89、3.78、7.56g/kg/d地鳖虫水煎萃取物,观察其对4周喂养小鼠免疫调节作用。地鳖虫水煎萃取物对小鼠廓清指数和吞噬指数明显增高;血清溶血素抗体滴度水平增加,小鼠脾细胞抗体生成有促进作用;中、高剂量组NO含量极显著高于空白对照组,碱性磷酸酶和酸性磷酸酶活性只有高剂量组高于对照。试验结果表明地鳖虫对机体免疫有提高的作用,说明地鳖虫具有免疫调节功能,具有较高的资源开发利用价值。

This paper describes the results of experiments to test the effect of Eupolyphaga sinensis Walker on the immune systems of mice.Mice were given a decoction of E.sinensis in water at doses of 1.89 g /kg /d,3.78 g /kg /d,7.56 g /kg /d for 4 weeks,after which their immune function was studied.The results indicate that E.sinensis observably enhanced the carbon expurgatory index and phagocytic index.The half of hemolysis values in serum of treated mice increased compared to the control group.Furthermore,serum NO content in all treatment groups was higher than that of the control group whereas acid phosphatase and alkalinity phosphatase activity was only significantly higher in the high dose group relative to the control group.We conclude that E.sinensis can enhance the immune function of mice and therefore that this insect has potential as a health food supplement.