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microRNA在神经系统疾病发病机制中的作用 被引量：7

Effect of microRNA on pathogenesis of nervous system disease
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摘要 一、microRNA概述 microRNA简称miRNA,是一种内源性非编码单链小分子RNA,大小约为22个核苷酸.在结构上,编码miRNA的基因由RNA聚合酶Ⅱ转录,只有少数由RNA聚合酶Ⅲ转录[1];接着原始转录本被RNA酶ⅢDrosha加工而产生Pre-miRNA：随后Pre-miRNA在Ran-GTPase依赖的转运蛋白exportin-5作用下易位到细胞质中[2],被另一个RNA酶ⅢDicer进一步加工,切割产生成熟的单链miRNA,其5＇端最弱碱基配对区被优先装载入RNA诱导的沉默复合物（RISC）中,miRNA与靶标mRNA的结合发生在RISC内,并且靶标的沉默需要Argonaute蛋白质家族的存在;随后miRNA与靶标mRNA 3＇端配对并沉默其翻译成蛋白质.基因表达的转录后调控是一种对中枢神经系统神经元发育和行使正常生理功能重要的调控机制,而miRNA的研究补充了这一调控,对神经系统疾病的研究进入了新的领域.
作者 肖占琴 陶树新 陈阳美
机构地区 重庆医科大学附属第二医院神经内科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2011年第2期204-206,共3页 Chinese Journal of Neuromedicine
基金 重庆市卫生局医学科研重点项目（2010-1-36）
关键词 微RNAS 神经元 神经系统疾病 microRNAs Neuron Nervous system disease
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献26

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二级参考文献31

  • 1Filipovic-Sadic S,Sah S,Chen L,et al.A Novel FMR1 PCR Method for the Routine Detection of Low-Abundance Expanded Alleles and Full Mutations in Fragile X Syndrome[J].Clin Chem,2010,56(3):399-408.
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共引文献9

同被引文献131

引证文献7

二级引证文献28

中华神经医学杂志
2011年 第2期

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