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山东汉族梅毒患者与HLA-A、B等位基因的相关性研究

Association of HLA-A and -B alleles with syphilis in Shandong Han population
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摘要 目的 探讨山东汉族梅毒患者与HLA-A、B等位基因的相关性.方法 采用PCR-序列特异性寡核苷酸探针杂交(PCR-SSOP)方法对205例山东汉族梅毒患者与5844例山东汉族正常对照的HLA-A、B等位基因表现频率进行检测.结果 梅毒患者组HLA-A*02,B*15、40等位基因频率高于对照组(P值均<0.01;Pc值均<0.05),HLA-A*26等位基因频率低于对照组(P=0.003;Pc=0.039),HLA-B*15、40等位基因频率在显性梅毒组高于对照组(P值均<0.01;Pc值均<0.05),HLA-A*02、11、29,B*15、40等位基因频率在隐性梅毒组高于对照组(P值均<0.01;Pc值均<0.05),HLA-A*30、33等位基因频率在隐性梅毒组低于对照组(P值、Pc值分别为0.002、0.026;0.001、0.013),HLA-A*30等位基因频率在显性梅毒组高于隐性梅毒组(P=0.001;Pc=0.013).结论 HLA-A*02,B*15、40等位基因可能与山东汉族梅毒相关,HLA-A*30可能与山东汉族显性梅毒相关,HLA-A*02、11、29可能与山东汉族隐性梅毒相关. Objective To investigate the association of HLA-A and -B alleles with syphilis in 5handong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5944 normal human controls by PCR-sequence specific oligouueleotide probe (PCR-SSOP) method. Results The patients with syphilis showed a higher frequency of HLA-A*02, B*15, B*40 alleles (all P 〈 0.01, Pc 〈 0.05) and a lower frequency of HLA-A*26 allele (P = 0.003, Pe = 0.039) than the normal human controls did. There was an increased frequency of HLA-B*15 and B*40 alleles in patients with symptomatic syphilis (both P 〈 0.01, Pc 〈 0.05 ), as well as an elevated frequency of HLA-A*02, 11, 29, B* 15 and 40 alleles (all P 〈 0.01, Pe 〈 0.05) and a decreased frequency of HLA-A*30 and 33 in patients with asymptomatie syphilis (P -= 0.002, 0.026, Pc = 0.001, 0.013 respectively), compared with the normal human controls. The frequency of HLA-A*30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatie syphilis (P = 0.001, Pc = 0.013). Conclusions There seems to he an association between HLA-A*02, B*15 and B*40 alleles and syphilis, between HLA-A*30 allele and symptomic syphilis, and between HLA-A*02, 11 and 29 alleles and asymptomatic syphilis, in Shandong Han population.
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2011年第2期124-126,共3页 Chinese Journal of Dermatology
基金 国家"十一五"攻关项目(2006BA702B01)
关键词 梅毒 HLA抗原 等位基因 Syphilis HLA antigens Alleles
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参考文献9

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